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Science Resources: Neuroscience

Amy Janes
August 6, 2018

Dr. Amy Janes, assistant professor of psychiatry at Harvard Medical School, provides a general introduction to the brain networks affected by substance abuse disorders. The following questions are addressed:

  • What is addiction?
  • What is the reward circuit in the brain, and how is it affected by addiction?
  • What are the underlying brain mechanisms involved in tolerance, withdrawal, and the cycle of substance abuse?
  • How does the brain change with repeated substance abuse?


  • to understand how addiction is defined and how certain brain pathways are changed by substance use disorders
  • to understand how changes in the brain related to substance abuse can present challenges to treatment

To learn more about Dr. Janes, click here.

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